3-(4-PHENYLBENZOYL)PROPIONIC ACID
Lederfen
CAS: 36330-85-5
Molecular Formula: C16H14O3
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Names and Identifiers
| Name | Lederfen |
| Synonyms | cl82204 FENBUFEN Fenbufen Lederfen 4-biphenyl-4-yl-4-oxobutanoate 4-(4-BIPHENYL)-4-OXOBUTYRIC ACID 3-(4-PHENYLBENZOYL)PROPIONIC ACID 4-(4-BIPHENYLYL)-4-OXOBUTYRIC ACID 4-(biphenyl-4-yl)-4-oxobutanoic acid diphenyl-4-gamma-oxo-gamma-butyricacid GAMMA-OXO(1,1'-BIPHENYL)-BUTANOIC ACID 3-(4-Biphenylylcarbonyl) propionic acid GAMMA-OXO-[1,1'-BIPHENYL]-4-BUTANOIC ACID |
| CAS | 36330-85-5 |
| EINECS | 252-979-0 |
| InChI | InChI=1/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)/p-1 |
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Physico-chemical Properties
| Molecular Formula | C16H14O3 |
| Molar Mass | 254.29 |
| Density | 1.1565 (rough estimate) |
| Melting Point | 184-187 °C (lit.) |
| Boling Point | 357.5°C (rough estimate) |
| Flash Point | 252.3°C |
| Water Solubility | 2.212mg/L(25 ºC) |
| Solubility | Soluble in glacial acetic acid, ethanol, chloroform, ether and propylene glycol, almost insoluble in water and petroleum ether. |
| Vapor Presure | 1.21E-09mmHg at 25°C |
| Appearance | White solid |
| Merck | 13,3990 |
| pKa | pKa 4.3(H2O tunde?ned Iunde?ned) (Uncertain) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to light |
| Refractive Index | 1.5600 (estimate) |
| MDL | MFCD00056701 |
| Physical and Chemical Properties | White or off-white needle-like crystals. Melting point 185-187 °c. Soluble in acetic acid, ethanol, chloroform, ether, slightly soluble in ketone, almost insoluble in water and petroleum ether. Odorless and sour. |
| Use | Non-steroidal anti-inflammatory, antipyretic, analgesic |
| In vivo study | Fenbufen and its metabolites exert mitochondrial toxicity by inhibiting ATP synthesis. Fenbufen inhibits the release of prostaglandins by 80% and reduces the rate of protein synthesis in normal and hypertrophied muscles. |
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DV1761000 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte) |
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Standard
Authoritative Data Verified Data
This product is 3-(4-biphenylcarbonyl) propionic acid. Calculated as dry product, it shall contain no less than 98.5% of C16H1403.
Last Update：2024-01-02 23:10:35
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is soluble in ethanol, almost insoluble in water; Soluble in hot alkali solution.
melting point
The melting point of this product (General 0612) is 185~188°C.
Last Update：2022-01-01 11:55:13
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Differential diagnosis
Authoritative Data Verified Data
- take about 0.1g of this product and add 2ml sulfuric acid. The solution shows orange-red color. After diluted with water, the color will disappear and white precipitate will form.
- take about 0.1g of this product, add 5ml of anhydrous ethanol, heat to dissolve, let it cool, drop add ferric chloride solution, and generate orange precipitate.
- take this product and add anhydrous ethanol to make a solution containing about 5ug per lml. According to ultraviolet-visible spectrophotometry (General rule 0401), there is maximum absorption at the wavelength of 281nm, there is minimal absorption at a wavelength of 238nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 170).
Last Update：2022-01-01 11:55:14
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Exam
Authoritative Data Verified Data
chloride
take anhydrous sodium carbonate 2G, spread on the bottom and around the Crucible, then take the product l. Put it on anhydrous sodium carbonate, wet it with a small amount of water, and after drying, burn it with small fire to make it charring, then burn it at 700~800°C to make it ash completely, and let it cool, add an appropriate amount of water to dissolve, filter, wash the Crucible and filter with water, combine the filtrate and wash solution, put it in a 50ml measuring flask, dilute it with water to the scale, shake well, take 10ml with precision, add water to make 25ml, check according to law (General rule 0801), and compare with the standard sodium chloride solution of 0.03% with the control solution made by the same method, not deeper ().
sulfate
take 10.0ml of the filtrate remaining under the above chloride item, add water to make 25ml, check according to law (General rule 0802), and standard potassium sulfate solution 2.0ml of control solution prepared by the same method should not be deeper (0.1%).
Related substances
take about 50mg of this product, put it in a 25ml measuring flask, Add 10ml of dimethylformamide, shake to dissolve, dilute to the mark with solvent [1.8% glacial acetic acid solution-acetonitrile (68:32)], shake well as a test solution; Take 1 ml in a 100ml measuring flask, dilute with solvent to scale, shake well, and use as a control solution; Take appropriate amounts of fenbufen and ketoprofen respectively, the solvent was dissolved and diluted to prepare a mixed solution containing about 0.02mg of fenbufen and 0.05mg of ketoprofen per 1 ml as a system-suitable solution. According to high performance liquid chromatography (General 0512) test, silica gel bonded with eighteen alkyl silane was used as filler; Mobile phase A was 1.8% glacial acetic acid solution; Mobile phase B was acetonitrile; Flow rate was 1.5ml per minute; the detection wavelength was 283nm; The column temperature was 30 ° C.; The gradient elution was performed according to the following table. Take the system applicable solution 20u1 and inject it into the liquid chromatograph. The resolution of ketoprofen peak and fenbufen peak should be greater than 5.0. 20 u1 of each of the control solution and the test solution were accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram was recorded. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0% ) , and the sum of each impurity peak area shall not be greater than 2 times the area of the main peak of the control solution (2.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
arsenic salt
take 10.0ml of the filtrate remaining under the above chloride item, add 5ml of hydrochloric acid and 13ml of water, and check according to law (General Principles 0822, first law), and shall comply with the regulations (0.001%).
Last Update：2022-01-01 11:55:15
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Content determination
Authoritative Data Verified Data
take 0.4g of this product, precision weighing, add 50ml of neutral ethanol, dissolve in hot water, cool, add 2 drops of phenolphthalein indicator solution, and use sodium hydroxide titration solution (0.lmol/L) titration. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 25.43mg of C16H1403.
Last Update：2022-01-01 11:55:15
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Category
Authoritative Data Verified Data
antipyretic analgesic, non-steroidal anti-inflammatory drugs.
Last Update：2022-01-01 11:55:15
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:55:16
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Fenbufen tablets
Authoritative Data Verified Data
This product contains fenbufen (C16H1403) should be 90.0% to 110.0% of the label.
trait
This product is white tablet or white-like tablet.
identification
- take an appropriate amount of fine powder of this product (about 0.2g of fenbufen), add 20ml of anhydrous ethanol, put it on a water bath and heat it to dissolve fenbufen, let it cool, filter it, and take 5ml of the filtrate, five drops of ferric chloride solution were added to form an orange precipitate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of fine powder of this product (about equivalent to fenbufen lOOmg), add 10ml of ethyl alcohol, grind and dissolve, filter, filter into human petroleum ether, rapidly stir to crystallize, and place for 15 minutes, the residue was collected by filtration through a vertical melting glass funnel, dried at 105 ° C. For 15 minutes, and measured by the method. The infrared absorption spectrum of this product should be consistent with the spectrum of the control (Spectrum set 170 figure).
examination
- Related Substances: take an appropriate amount of fine powder of this product (about 0.lg of fenbufen), put it in a 50ml measuring flask, add 20ml of N ,N-dimethylformamide, and shake to dissolve it, dilute to the scale with solvent [1.8% glacial acetic acid solution-acetonitrile (68:32)], shake well, filter, and take the continued filtrate as the test solution; Take 1 ml with precision, set in a 100ml measuring flask, dilute to the scale with solvent, and shake to serve as a control solution. The determination was carried out according to the method described for the related substances of fenbufen. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0% ) , and the sum of each impurity peak area shall not be greater than 2 times the area of the main peak of the control solution (2.0%).
- dissolution the dissolution of this product was determined according to the dissolution and release determination method (General rule 0931 second method), and the dissolution medium was 7.6 phosphate buffer (pH 100), and the rotation speed was rpm, operate according to law, after 45 minutes, take 10ml of the solution, filter, take 2ml of the filtrate, and put it in a 50ml measuring flask (0.15g specification) or a 100ml measuring flask (0.3g specification), dilute to scale with dissolution medium and shake. The absorbance was measured at a wavelength of 0401 NM according to UV-Vis spectrophotometry (General rule 868), and the elution amount of each tablet was calculated as the absorption coefficient of C16H1403 was. The limit is 65% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; 1.8% glacial acetic acid solution-acetonitrile (56:44) as mobile phase; The detection wavelength was 280mn. The number of theoretical plates is not less than 5000 calculated from the fenbufen peak.
- determination of 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 0.15g equivalent to fenbufen), put it in a 100ml measuring flask, add methanol 30ml, ultrasonic for 15 minutes to dissolve fenbufen, dilute to the scale with mobile phase, shake well, filter, take the filtrate 2ml accurately and put it in a 50ml measuring flask, dilute to the scale with mobile phase, shake well, as a sample solution, take 10u1 injection liquid chromatograph for precise measurement, record chromatogram; Take additional fenbufen reference substance I5mg for precise weighing, put it in 10ml measuring flask, add methanol 3ml, ultrasonic 15 minutes to dissolve, with the mobile phase diluted to scale, shake, precision take 2M l 50ml flask, with the mobile phase diluted to scale, shake, the same method. According to the external standard method to calculate the peak area, that is.
category
Same as fenbufen.
specification
(1)0.15g (2)0.3g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:55:17
3-(4-PHENYLBENZOYL)PROPIONIC ACID - Fenbufen capsules
Authoritative Data Verified Data
This product contains fenbufen (C16H1403) should be 90.0% to 110.0% of the label.
trait
The content is white or off-white powder.
identification
- take an appropriate amount of the content of this product (about 0.2g of fenbufen), add 20ml of anhydrous ethanol, put it on a water bath and heat it to dissolve fenbufen, let it cool, filter it, and take 5ml of the filtrate, five drops of ferric chloride solution were added to form an orange precipitate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- Take 2 capsules of this product, grind, add ethanol or acetone 10ml, dissolve, filter, filter into human petroleum ether, quickly stir to crystallize, place for 15 minutes, the residue was collected by filtration through a vertical melting glass funnel, dried at 105 ° C. For 15 minutes, and measured according to the law. The infrared absorption spectrum of this product should be consistent with the spectrum of the control (Spectrum set 170 figure).
examination
- Related substances take an appropriate amount of the content of this product (about 0.lg of fenbufen), put it in a 50ml measuring flask, add 20ml of N,N-dimethylformamide, shake to dissolve it, dilute to the scale with solvent [1.8% glacial acetic acid solution-acetonitrile (68 :32)], shake well, filter, and take the continued filtrate as the test solution; Take 1ml with precision, set in a 100ml measuring flask, dilute to the scale with solvent, and shake to serve as a control solution. The determination was carried out according to the method described for the related substances of fenbufen. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0%), and the sum of each impurity peak area shall not be greater than 2 times the area of the main peak of the control solution (2.0%).
- dissolution the dissolution of this product was determined according to the dissolution and release determination method (General rule 0931 method 1), and the dissolution medium was 7.6 phosphate buffer (pH 100), and the rotation speed was rpm, operate according to law, after 45 minutes, take 10ml of the solution, filter, take 2ml of the filtrate with precision, put it in a 50ml measuring flask, dilute it to the scale with dissolution medium, and shake well. The absorbance was measured at a wavelength of 0401 mn according to UV-Vis spectrophotometry (General 868), and the amount of dissolution of each particle was calculated as the absorption coefficient of C16H1403 was. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability silica gel bonded with eighteen alkyl silane was used as filler; 1.8% glacial acetic acid solution-acetonitrile (56:44) was used as mobile phase; The detection wavelength was 280nm. The number of theoretical plates is not less than 5000 calculated from the fenbufen peak.
- determine the contents under the item of difference in loading, mix well, weigh an appropriate amount (about 0.15g of fenbufen) accurately, put it in a 100ml measuring flask, and add 30ml of methanol, ultrasonic for 15 minutes to dissolve fenbufen, dilute to the scale with mobile phase, shake well, filter, take the filtrate 2ml accurately and put it in a 50ml measuring flask, dilute to the scale with mobile phase, shake well, as a sample solution, take 10m1 injection liquid chromatograph for precise measurement, record chromatogram; Take 15mg fenbufen reference substance for precise preparation, put it in 10ml measuring flask, add 3ml methanol, ultrasonic 15 minutes to dissolve, with the mobile phase diluted to scale, shake, precision take 2ml into 50ml flask, with the mobile phase diluted to scale, shake, the same method. According to the external standard method to calculate the peak area, that is.
category
Same as fenbufen.
specification
0.15g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:55:18
Supplier List
Multiple Specifications
Product Name: Fenbufen Visit Supplier Webpage Request for quotationCAS: 36330-85-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: Fenbufen Visit Supplier Webpage Request for quotationCAS: 36330-85-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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